This polyclonal antibody recognizes an oncofetal glycoprotein with a single chain of 70kDa, which is identified as alpha fetoprotein (AFP). It is highly specific to AFP and shows no cross-reaction with other onco-fetal antigens. AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors. This antibody is excellent for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues.