Alpha-1-Antichymotrypsin (AACT)

Cat. No. : 0011
Name: Alpha-1-Antichymotrypsin (AACT) Rabbit polyclonal Antibody
Type: Rabbit Polyclonal
Immunogen: Purified human alpha-1-antichymotrypsin.
Species Reactivity: Human, others not-known.
Clone: /
Isotype: Rabbit IgG
Cellular Localization: Cytoplasmic
Concentrated antibody Dilution: 1:120-1:240
Antigen retrieval:  Citrate
Intended Use: IVD 
Storage: Store at 2-8°C. Do not freeze.

Recognizes a protein of 62kDa which is identified as Alpha-1-Antichymotrypsin (Alpha-1-ACT). This polyclonal antibody is highly specific to Alpha-1- ACT and shows no cross-reaction with other related proteins. Alpha 1-ACT is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT. A higher proportion of serum PSA is complexed to Alpha-1-ACT in prostate cancer than in benign prostate hyperplasia.

Cat. No. Size
R-0011-06 Ready to Use: 6mL
M-0011-1.0 Concentrated: 1mL
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