Galectin-3 is a member of the beta-galactosidase binding lectin family. It is involved in several biological events including binding to the basement membrane glycoprotein laminin. Cell surface galectin-3 may be involved in homotypical cell adhesion and is down-regulated in colon cancer as the disease progresses. This down-regulation has also been examined in breast carcinoma with a similar correlation of expression observed. Down-regulation of galectin-3 could be one of the many events that enable cancer cells to interact with laminin to facilitate invasion and metastasis and may indicate activation of the invasive and metastasis phenotype in various tumour types. Galectin-3 has been detected in anaplastic large cell lymphomas whereas galectin-3 is not detected in Reed Sternberg cells or variants of Hodg in’s disease. This antibody may be of value in the study of disease progression of cancer cells and in the characterisation of anaplastic large cell lymphomas.